How polymerase detect error? The polymerase checks whether the newly-added base has paired correctly with the base in the template strand. If it is the correct base, the next nucleotide is added. If an incorrect base has been added, the enzyme makes a cut at the phosphodiester bond and releases the incorrect nucleotide.
How does DNA polymerase detect errors? During DNA synthesis, most DNA polymerases “check their work,” fixing the majority of mispaired bases in a process called proofreading. Immediately after DNA synthesis, any remaining mispaired bases can be detected and replaced in a process called mismatch repair.
How does DNA polymerase proofread? In bacteria, all three DNA polymerases (I, II and III) have the ability to proofread, using 3′ → 5′ exonuclease activity. When an incorrect base pair is recognized, DNA polymerase reverses its direction by one base pair of DNA and excises the mismatched base.
How do excision repair enzymes know which strand is incorrect? Mismatch repair enzymes detect distortions caused by mismatched bases inserted during DNA synthesis. Although the enzyme can find the site of the mutation by detecting the distortion caused by the mismatched bases, additional information must be available to indicate which strand is incorrect.
Error-prone polymerase.mp4
How polymerase detect error? – Similar Questions
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Can plastic be detected in a metal detector?
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